Approved Research

The impact of pharmacogenomics on drug response

Lay summary

Pharmacogenomics (PGx) is the study of the impact of genetics on response to medications. There is a significant amount of evidence that supports the use of PGx for tailoring treatment for patients. Incorporation of PGx has improved outcomes for many drugs. However, there is still a lot of variability in the response to medications in terms of adverse drug reactions and efficacy with adverse drug reactions remaining as one of the most common reasons for hospitalization. Our goal is to utilize large datasets such as UK Biobank to identify clinical and genetic factors that drive the variability in response to medications. This information gained from this study can guide future research towards further testing of the identified variants and to guide the design of clinical trials.