Approved Research

The interaction of type 2 diabetes mellitus and hypertension in aortic disease.

Lay summary

Aortic aneurysm and aortic dissection is a series of highly lethal diseases, the most severe outcome is rupture of the aorta, whose mortality is desperate. T2D and hypertension have been known as traditional cardiovascular risk factors, but recent research found that T2D seems to be protective against aortic disease. As T2D complicated with hypertension is quite common, how they interact with each other in aortic disease is important for clinicians to evaluate and manage patients. Socioeconomic factors and lifestyle are also known to play some roles in T2D and hypertension, thus whether they can impact aortic disease through T2D and hypertension can be inspiring for clinicians guiding individuals. Furthermore, medication for T2D and hypertension may affect aortic diseases, thus what combination of them can perform the best effect on T2D, hypertension, and aortic diseases is waiting to be found out for better managing this population. Hereditary factors impact individuals on life scale, therefore, recognizing high-risk gene variance helps in identifying high-risk individuals in a quite early phase to prevent from aortic diseases, and for analyzing related bioinformatic data, we hope that we can recognize some targets for future therapy so that to postpone the progression even prevent the onset of aortic diseases in T2D patients.

Our study supposed to be last for three years, with our study results,  we expect to clarify how the interaction between T2D and hypertension affects the onset and even progression of aortic diseases, and how they interact with each other. Our results are supposed to be helpful for clinicians to evaluate high-risk individuals so that they can be brought into early follow-up to prevent aortic diseases. Our results will propose an optimized medical combination and life guideline to better protect T2D patients from aortic diseases. Also, potential therapeutic targets will be proposed to help with guiding clinical management or future studies.