Approved Research

The risk factor and underlying mechanism of Clonal Hematopoiesis Indeterminate Potential (CHIP) in cardiocerebrovascular diseases and renal diseases

Lay summary

Clonal Hematopoiesis Indeterminate Potential (CHIP) is a common phenomenon that is present in the normal population and is also a causative and prodromal stage of cancer and cardiovascular disease. Identifying the relationship between CHIP and disease and pathogenic mechanisms is important for early screening, targeted therapy and reversal of progression.

Calcific aortic valve disease (CAVD) is a common cardiovascular disease, with a prevalence of more than 25% in people over 65 years of age. However, studies on the role of CHIP in CAVD are limited. Renal disease is an important risk factor for CAVD, but the specific mechanisms have not been adequately investigated.

This study has important public health implications. With an aging population, cardiovascular disease and kidney disease have become one of the major global health problems, imposing a huge burden on individuals and society. Our research results will contribute to genetic testing to help potentially at-risk populations to identify risks early and to prevent and treat them early.