Approved Research

The Risk Factors and Prognosis of Cardiovascular-Kidney-Metabolic (CKM) Conditions

Lay summary

Aims: The present project aims to investigate the risk factors for the CKM conditions, as well as the prognostic value of CKM multimorbidity. The potential risk factors for CKM conditions include the mass and the distribution of adipose tissue, the sedentary lifestyle, and lack of physical activity (both duration and intensity) etc. We also intend to evaluate the impact of CKM multimorbidity on mortality.

Scientific rationale: Cardiovascular, kidney, and metabolic (CKM) conditions are among the leading global and regional causes of death. Moreover, adults with cardiocasvular disease (CVD), impaired renal function, or type 2 diabetes mellitus (T2DM) had a remarkably shorter life span compared with their counterparts without the corresponding conditions. The concurrence of CKM conditions constitutes a global challenge in light of the current demographic transition towards an aging society. Traditional risk factors for CKM conditions include hypertension, obesity, dyslipidemia. However, the association of various modifiable lifestyles (such as physical activity) and the body composition characteristic with CKM conditions. In addition, few studies examined the association of CKM multimorbidity with mortality.

Project duration: 3 years.

Public health impact: The present project will underscore the importance of prevention and treatment of CKM multimorbidity. On one hand, attempts on lifestyle modification, addressing measured and unmeasured metabolic components, should be extensively adopted in the general population to avert the development of CKM multimorbidity. On the other hand, the advocate for management integration and multidisciplinary care should be further strengthened clinically to address CKM problems cohesively and effectively in our current medical context and enhance the efficiency of patient-centered care.