Approved Research

Uncovering the Role of the Complement Trimolecular Complex in Age-Related Macular Degeneration

Lay summary

This study aims to identify genetic risk factors for age-related macular degeneration (AMD), a leading cause of irreversible sight loss in older adults. We will use data from the UK Biobank to conduct genome-wide association studies identifying mutations associated with AMD, focusing on genetic interactions within the complement system - a group of proteins that play a role in the development of AMD. The findings of our study have the potential to significantly advance our understanding of AMD and could lead to the development of new, personalised therapies for the condition, improving the lives of millions of individuals affected by AMD and their caregivers.