Understanding brain structure and function as an intermediary phenotype to chronic pain
Approved Research ID: 20802
Approval date: July 23rd 2020
Patients suffering from chronic pain commonly report emotional distress due to their pain. As a result, chronic pain patients are at risk for developing a variety of disorders including depression, anxiety, and addictive behaviours. They are also at risk of poor health behaviours, such as physical inactivity, malnutrition, substance use, and poor sleep that may contribute to the maintenance or worsening of their pain.
Investigating the role of these accompanying conditions, each with distinct genetic predispositions, is therefore crucial to understand brain structure and function as an intermediary phenotype to chronic pain. This will be done by incorporating these various disorders, mood-related measures, and health behaviours in one overarching burden score of pain and its chronicity. The proposed data request will include online follow-up questionnaires (mental health and pain-related measure), as well as common medical and health-related measures (general health, blood pressure, diagnosis, among others).