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Approved Research

Understanding the genetic and environmental risk factors and genotype-environment interaction in cardiovascular diseases for precision medicine

Principal Investigator: Dr Sen Li
Approved Research ID: 63121
Approval date: July 17th 2020

Lay summary

Cardiovascular disease (CVD) is a group of disorders with complex and multifactorial nature. The proposed project is going to reveal novel genetic and environmental risk factors of various types of CVD. Moreover, genotype-environment interaction of these risk factors in CVD will also be investigated. This interaction is of particular importance because people with different genotype may have different sensitivity to a given environmental risk factor, or response differently to a certain treatment for CVD.

The estimated duration of this project is 3 years. The proposed project is expected to provide useful information for a better understanding of CVD pathogenesis. By integrating both genetic and environmental variability of individuals, the current project may contribute to the development of precision medicine for CVD prevention.