Approved Research

Unrevealing the association between chronic pain and dietary patterns

Lay summary

Aims: In this study, we aim to comprehensively investigate the association between dietary patterns and chronic pain. First, through a cross-sectional analysis, we seek to identify dietary patterns associated with the presence of chronic pain. Second, in a prospective analysis, we aim to explore the longitudinal relationship between dietary patterns and the risk of onset of chronic pain.

Scientific Rationale: Chronic pain exerts a significant socioeconomic impact, affecting between one-third to half of the UK population, yet remains challenging to treat. While comorbidities contributing to chronic pain are well-acknowledged, lifestyle factors are frequently overlooked. Recently, nutrition, as a major modifiable lifestyle factor, is gaining increased attention in the chronic pain field. Previous research has revealed associations between specific food intake and chronic pain. The complex relationship between nutrition and chronic pain extends beyond individual nutrients, impacting neuroinflammation, a key process in pain modulation. Compared to specific food intake, overall dietary pattern analysis is suggested as a more robust way of investigating diet-disease interaction as this complex interaction tends to be difficult to capture with a single nutrient intake analysis. Dietary pattern analysis enables considering the interrelationship between individual nutrients in a diet and provides more comprehensive information on the overall dietary features of individuals.

Project Duration: This research is anticipated to take three years. Throughout this timeframe, we will curate and conduct a comprehensive analysis of the data, taking into account all relevant factors that may impact the outcomes.

Public Health Impact: Findings from this project will provide insight into the association between dietary patterns and chronic pain which can have a significant impact on public health efforts on preventing and managing chronic pain. Identification of this link has the potential to inform targeted interventions and lifestyle modifications to reduce the risk of chronic pain onset. Moreover, this research aligns with broader public health goals, emphasizing empowering individuals to adopt healthier lifestyles for enhanced overall well-being.