Approved Research

Using genetics, proteomics, and metabolomics in the study of cardiometabolic disease

Lay summary

In this research program we intend to use information of genes, proteins and small molecules (metabolites) to study mechanisms in the body that could lead to cardiovascular disease, such as stroke, myocardial infarction and heart failure, as well as diabetes, high lipid levels and high blood pressure. The discovery of new mechanisms in this respect could potentially lead to new pharmaceutical drugs or new non-pharmacological interventions to lower the burden of cardiovascular disease. A specific focus is on mechanisms whereby obesity could induce cardiovascular disease, since obesity is increasing and is linked to future cardiovascular disease.

The analysis of multiple genes, proteins, as well as metabolites, in this research project is very programming and computer-demanding and will take 2-3 years to accomplish.