Research question: The magnitude of nervous system and brain structure changes induced by cardiovascular diseases is unclear.
Aims: We are committed to exploring unknown territory of heart-brain cross-talk, seeking out novel evidence and deciphering the underlying mechanisms. By doing so, we aim to establish new diagnostic approaches and formulate innovative therapeutic strategies that could potentially revolutionize the way we address the complex interplay between heart and brain health.
Scientific rationale: In cardiac dysfunction strong haemodynamics and neuronal signaling feedback interactions between heart and central nervous system exist that are able to bidirectionally provoke acute or chronic functional impairment. Cerebral injury secondary to cardiac dysfunction may include sudden stroke, cognitive decline (which might end up as dementia), and depression. Brain stem functions are related to the heart-brain interaction. In cardiac dysfunction, it’s known that the neurohormonal control and neuronal reflex circuits get out of balance. In this project, we will explore and identify the principal aspects of the pathophysiologic interactions between heart and brain that are associated with cardiac dysfunction. These aspects encompass a range of conditions and mechanisms, including stroke, the impact on cognitive function and brain structure, the relationship with depressive disorders, as well as alterations in neurovegetative control and the regulation of neuronal cardiovascular reflexes.
