This research dives into the development and progression of chronic diseases, including, but not limited to, cardiovascular disease, respiratory disease, metabolic disease, and cancer. It aims to 1) track how individuals transition from healthy states to single chronic disease, then multimorbidity, and ultimately death. 2) identify distinct patterns in this progression, considering which diseases co-occur and the order of their appearance. 3) investigate the causal relationships between lifestyle factors, genetic predispositions, and the development and progression of chronic diseases. Identify potential mediators and modifiers that influence these pathways. 4) assess the prevalence and impact of overdiagnosis in chronic diseases, including the identification of factors contributing to overdiagnosis.
