Research Questions
1.Are environmental and lifestyle factors systematically associated with proteomic and metabolomic profiles at the population level?
2.Are proteomic and metabolomic features independently associated with the risk of incident chronic diseases?
3.To what extent do multi-omics features mediate the associations between environmental or lifestyle factors and chronic disease risk?
4.Do shared molecular pathways and disease-specific molecular features exist across different chronic diseases?
5.Does genetic susceptibility modify the effects of environmental and lifestyle factors on multi-omics profiles and disease risk, leading to high-risk subgroups?
Research Objectives
1.Identify proteomic and metabolomic features associated with a broad range of environmental and lifestyle factors;
2.Evaluate prospective associations between multi-omics features and the risk of multiple chronic diseases;
3.Elucidate the mediating roles of multi-omics features and the biological pathways linking exposures to disease outcomes;
4.Explore interactions between genetic susceptibility and environmental or lifestyle factors;
5.Provide molecular-level evidence to support early disease detection, risk stratification, and precision prevention.
Scientific Rationale
1.Genetic susceptibility, captured by polygenic risk scores , contributes to disease risk but does not fully explain inter-individual heterogeneity.
2.Proteomic and metabolomic profiles reflect downstream biological responses to genetic, environmental, and lifestyle factors, capturing systemic processes and proximal metabolic phenotypes.
3.Lifestyle behaviors and social determinants, including diet, physical activity, smoking, socioeconomic status, education, and psychosocial stress, shape biological pathways and vulnerability to chronic disease.
