Aims:
Our project aims to uncover the lingering risks of cardiovascular diseases in people who have managed to get their cholesterol and other blood fats to healthy levels. We want to find out why some people still face health issues related to heart diseases even when their lipid levels are under control.
Scientific Rationale:
Cardiovascular diseases are a major cause of death and disability worldwide. High cholesterol and other lipid abnormalities are key risk factors, but even when these are well-managed, there’s still a risk. We suspect this leftover risk could be due to factors like diet, genes, and how the body processes certain substances. New technologies are giving us a chance to look at this in more detail.
Project Duration:
We plan to spend several years on this research to gather comprehensive data from participants, perform detailed analyses of dietary habits, plasma proteomics, metabolites, and polygenic risk scores, and then construct and validate a risk assessment model.
Public Health Impact:
Through this study, we aim to gain a more comprehensive understanding of the residual cardiovascular risk in patients with well-controlled dyslipidemia. By providing more precise risk assessment and management strategies for clinical practice, we hope to ultimately improve patient outcomes and quality of life. This research will contribute to the development of personalized medicine approaches, tailoring interventions to individual patient profiles, and enhancing the effectiveness of preventive measures against cardiovascular diseases.
