Research on environmental influences on cognition/ADRD has primarily focused on single exposures, suggesting air pollution, noise , limited greenspace , sunlight, and artificial nightlight exposure, are individually associated with heightened risks of ADRD, mental health problems, and sleep disturbances. In real world settings, however, people are often exposed to multiple adverse environmental factors simultaneously. These overlapping exposures may amplify health risks beyond the effects of individual factors. Understanding the aggregated impact of these exposures is essential for identifying high-risk combinations and evaluating the combined effects of multiple exposures on sleep and cognitive health in aging. This study will introduce an aggregated environmental exposure model to identify high-risk environmental combinations for sleep, mental health and AD/ADRD.
