Our long term goal is to promote healthy ageing in the general population based on new knowledge from individual ageing drivers. Our short term aims are: 1) Characterise DDR ageing signatures and 2) Validate the method in a big cohort of patients from the external databases We hypothesise that individual ageing trajectories can be used to tailor healthy ageing interventions. We strongly believe that implementing effective strategies to reduce disease burden among the elderly will significantly alleviate the strain on the healthcare system. Developing of affordable therapies that promote long-term health will thereby have a huge positive impact on society. the project duration will be 36 months.