Diabetes is a major global health concern, with rising prevalence linked to significant morbidity and mortality. This project aims to dissect the multifactorial nature of diabetes by examining the interplay of genetic predisposition, lifestyle factors (such as diet and physical activity), socioeconomic influences, and the gut microbiome in the onset and progression of diabetes, including its multimorbid consequences.
Key research questions include:
1. What genetic variants are associated with increased diabetes susceptibility in the UK Biobank cohort?
2. How do lifestyle and behavioral factors interact with genetic risk to influence diabetes development and outcomes?
3. What role do socioeconomic factors and environmental exposures play in diabetes management and health disparities?
4. How does the gut microbiome contribute to metabolic changes associated with diabetes?
The objectives of this study are to:
1. Identify genetic loci associated with diabetes and related conditions through genome-wide association studies (GWAS).
2. Assess the impact of dietary habits and physical activity on diabetes risk.
3. Investigate environmental influences, such as air pollution and socioeconomic status, on health outcomes.
4. Analyze the role of microbiome diversity in metabolic health and diabetes progression.
Utilizing the extensive dataset from the UK Biobank, this research will provide critical insights into the complex relationships among these variables, contributing to the development of personalized prevention and treatment strategies for diabetes. Ultimately, this project aims to improve health outcomes and clinical management for individuals with diabetes and multimorbidity.
