Cognitive impairment, abnormal eating behavior, and abnormal psychological status are common brain functional damages in patients with diabetes. These damages interact and promote each other, severely affecting the quality of life of patients, compliance with disease interventions, and treatment outcomes. As the main body of the modern medical, the biopsychosocial medical model emphasizes that medical staff should not only focus on the biological factors of the disease during diagnosis and treatment but also consider the of psychological and social factors on the disease. This allows for a comprehensive and effective understanding of the patient’s disease situation, planning of scientific and reasonable treatment schemes, promotion of the patient’s early recovery to a healthy state. The purpose of this study is to explore the neural mechanisms, interactions, and potential clinical applications of cognitive impairment, abnormal eating behavior, and psychological abnormalities in patients with diabetes based on the classic biopsychosocial medical model, multimodel MRI and bioinformatic analysis.