Objective: To retrospectively analyze a cohort of patients with central nervous system (CNS) inflammation to determine the occurrence of neurological complications.
Primary Endpoint: The occurrence of comorbidities and the time to comorbidity onset during a follow-up period of at least 5 years.
Secondary Endpoint: Time from diagnosis of CNS inflammatory disease to death.
Data Source: UK Biobank data.
Definitions:
CNS Inflammation: Approximately 40,000 adult patients diagnosed with CNS inflammatory diseases (based on ICD codes) and hospitalized between 2008 and 2017.
Control Group: Patients diagnosed with headaches between 2008 and 2017.
Comorbidities: Neurological and psychiatric conditions such as Amyotrophic Lateral Sclerosis, Brain Tumor, Hemorrhagic Stroke, Ischemic Stroke, Alzheimer’s Disease, Dementia, Parkinson’s Disease, Multiple Sclerosis, Major Depressive Disorder, Anxiety Disorder, Epilepsy, Neuromyelitis Optica, among others.
Analysis:
Survival analysis adjusted for age and sex.
Subgroup Analysis: Stratification by pathogen group where possible.