Research question
The prevalence of cardiometabolic diseases (CMDs), which defned as hypertension, diabetes, coronary heart disease (CHD) and stroke, is increasing rapidly. Considerable evidence has suggested that having any one of these conditions alone could increase the risk of mortality. Most studies have only focused on the cardiovascular diseases (CVD), but research on CMD is still relatively limited.
Objective
To address this gap, the present undertaking aims to employ an integrated approach, leveraging the wealth of genetics, metabolomics, proteomics, and comprehensive epidemiological data. Through multidimensional analyses, we aim to discover new risk factors, identify potential biomarkers, and understand causal relationships for various psychological disorders and cardiometabolic diseases.
Scientific rationale
Psychiatric disorders are associated with cardiometabolic diseases, but the exact relationship is unknown. To accomplish this, we will combine multi-omics (i.e., proteomics and metabolomics) and epidemiological data to discover novel risk factors, biomarkers and provide definitive evidence for known associations of psychological disorders and cardiometabolic diseases risk reported by traditional observational studies. Our endeavor will encompass the analysis of multi-omics and epidemiological information, enabling us to unravel new risk factors, identify potential biomarkers, and comprehend the intricate web of causal relationships underpinning various psychological disorders and cardiometabolic diseases. This comprehensive exploration will include conditions such as hypertension, diabetes, CHD, stroke, depression, anxiety disorder, and more.
