Research question
The human body is a complex network of biological systems, including gene-gene, hormone-hormone, and brain region-brain region interactions, which significantly influence mental and physical health and well-being. Current research indicates that these interactions, manifested through behaviors and emotion, are also affected by environmental factors. Despite advancements, the precise mechanisms of these influences remain unclear, highlighting a gap that this study aims to address.
Objective
This study focuses on understanding how social behaviors and emotional responses mediate the impact of biological interactions and how modifiable environmental factors. We will adopt an integrated and multidisciplinary approach, combining the power of genomics, transcriptomics, proteomics, metabolomics, and comprehensive epidemiological data. By conducting those methods, we strive to uncover novel insights into the biological chain interactions that influence health. Specifically, we aim to identify key molecular pathways, potential biomarkers, and causal relationships that drive the development and progression of various chronic diseases, including but not limited to diabetes, rheumatoid arthritis, and inflammatory bowel disease.
Scientific rationale
Emerging research suggests that interactions among genes, hormones, and brain regions can profoundly affect an individual’s mental and physical health. For instance, the self-esteem and burnout levels of monozygotic and dizygotic twins are influenced by shared genetic factors. The interplay between neuropeptides and cortisol during stressful situations helps regulate stress responses and emotional states. To accomplish this, we will combine multi-omics and epidemiological data to discover novel risk factors, biomarkers and provide definitive evidence for known associations of biological chain interactions and health reported by traditional observational studies.
