Metabolic syndrome have become a major challenge for global public health, which involve the dysregulation of immune cells and molecules. However, the mechanisms of these immune signatures and its interaction with genetic patterns across metabolic syndrome are still unclear. With access to the UK Biobank data including gene sequencing, metabolomics, Olink proteomics and health related outcomes data, we are interested in understanding the relationships between a list of immune signatures and relevance to metabolic syndrome related diseases. In addition, the effects of gene traits correlated with immune cells and molecules will be focused. During 36 months with UK Biobank data, this project will be centered around immune pathway biomarkers, and identify novel immune signatures for potential mechanism across different genetic patterns, thus supporting clinical studies of novel therapy targets for metabolic diseases.
