The global prevalence of brain health-related disorders continues to rise, posing a severe threat to human health. However, their path remains incompletely understood, and existing treatment options are limited. Early identification of high-risk factors remains a core challenge in public health, particularly in early detection and prevention. Although previous studies have revealed the roles of genetic, and lifestyle factors, the interactive effects and biological mechanisms of these factors require further exploration.This study leverages large-scale databases and integrates prior research findings to conduct multi-stage association analyses, aiming to elucidate the impact of these factors on the onset, progression, and prognosis of neurological disorders. By combining imaging and biomarker data, we will analyze potential mechanisms underlying baseline characteristics across different populations, assess the relative importance of each factor, and provide theoretical support for precision diagnosis and treatment strategies, thereby deepening the understanding of brain health disorders.
