Research questions:
1. Whether the bone mineral density could have an impact on the risk and prognosis of the cardiovascular diseases?
2. Do different bone metabolism indicators associate with cardiovascular diseases?
3. If patients with diabetes will have high risk of loss of bone mineral density?
4. If different dietary and metabolic factors could influence the risk and prognosis of cardiovascular diseases?
Objectives:
1. To investigate the association between bone mineral density and cardiovascular diseases and
2. To detect the link of different levels of bone metabolism indicators with the cardiovascular diseases.
3. To construct a predictive model of the diabetes patients for their potential bone loss.
4. To explore potential relationships between dietary and metabolic factors and cardiovascular diseases.
Scientific rationale:
Based on previous studies, cardiovascular diseases (CVD) referred to variable pathogenesis mechanisms. Metabolic disorders play an important role in CVD, especially in the coronary heart diseases. Conditions such as diabetes and metabolic syndrome have been reported associated significantly with the risk of CVD by many researchers. In addition, plenty of medical clinical and basic research had found that there were potential relationships between bone metabolism and CVD. Given lots of evidence, we want to utilize the unparalleled resource from UK biobank to furtherly investigate the novel features of bone metabolism and other metabolic conditions and to explore their impact on CVD. What’s more, we would also employ the Mendelian Randomization Analysis to find the potential causal relationships.
