Both hyperuricemia and periodontal diseases are highly prevalent non-communicable chronic diseases. They share many significant comorbidities such as diabetes, cardiovascular diseases, and chronic kidney diseases. Some scientific evidence has indicated a possible association between hyperuricemia and periodontal diseases. However, the strength of evidence is very weak, and the direction of association is unclear. It is necessary to answer whether there is a higher risk of periodontitis in populations with hyperuricemia/gout or vice versa. Hence, we would like to conduct clinical research based on the UK population using the UK Biobank data. The research might include a cross-sectional design and cohort design. We are prepared to consider three years to conduct the research project and publish the results. If hyperuricemia/gout were found to be positively connected with periodontal diseases or vice versa, given the high prevalence of both conditions and growing incidence of hyperuricemia, the global burden associated with them would be sharply increased. It would also increase the burden of many comorbidities that they share. Then it would shape clinical practice including the treatment regimen of both conditions and their comorbidities.
