We aim to study the association between a group of genes existing in different variants, that are believed to have an impact on how drugs act in our body and the respective health outcomes. In severe cases, persons with a specific gene variant are at risk of being hospitalized for adverse drug reactions when taking certain drugs – if the treatment is not adapted to their genetic profile. We aim to quantify these effects for different associations between genes, drugs, and health outcomes to provide more precise evidence for clinical practice as to who should be tested for which genes before starting drug therapy. We also aim to provide more evidence on which adverse drug reactions can be expected with certain gene variants. We hope that our research will thus help to reduce adverse drug reactions in the population and improve drug effectiveness. The project is planned for a duration of 3 years.
