Aim: Our study aims to investigate the association between static/dynamic systemic inflammatory markers and atherosclerotic cardiovascular disease (ASCVD). Specifically, systemic inflammatory markers include C-reactive protein (CRP), inflammatory cell counts, and cystatin C. Dynamic systemic inflammatory indices will be derived using trajectory analysis and unsupervised clustering methods. Additionally, we will incorporate exploratory analyses using inflammation indices developed from metabolomics or proteomics data to further characterize systemic inflammation. ASCVD is defined as coronary events (acute myocardial infarction and angina), cerebrovascular events (stroke and transient ischemic attack), and peripheral vascular disease.
Scientific Rationale: Recent studies reveal that more than half of ASCVD patients exhibit systemic inflammation, as evidenced by elevated CRP levels. Alarmingly, patients with higher levels of inflammation demonstrate significantly increased healthcare resource utilization, as well as elevated risks of major adverse cardiovascular events, heart failure, and mortality. Therefore, it is imperative to explore the causal relationship between systemic inflammation and ASCVD.
Project Duration: The study will utilize data from the UK Biobank and is expected to last for three years.
Public Health Impact: The findings will be disseminated through academic publications. In the future, precise monitoring and management of inflammation levels may enable more personalized approaches to cardiovascular disease prevention, ultimately improving patient outcomes and quality of life.
