Research questions: triglyceride-glucose (TyG) index is a reliable surrogate for insulin resistance (IR), which is associated with multiple metabolic disorders and cardiovascular diseases. Current research on the relationship between TyG and chronic pain is unclear.
Objectives: The purpose of this study is to investigate the correlation between TyG and its combined obesity indicators (TyG-WHtR, TyG-BMI, TyG-WC) and chronic pain.
Scientific rational: Using data from the UK Biobank, TyG and its combined obesity index (TyG-WHtR, TyG-BMI, TyG-WC) were calculated for each participant according to the formula. Logistic regression, restricted cubic spline (RCS), subgroup analysis, and receiver operating characteristic (ROC) curve were used to analyze the correlation between TyG and combined obesity indicators and chronic pain. Two-sample Mendelian randomization (TSMR) was used to analyze the causal relationship between TyG and combined obesity indicators with chronic pain.
