Aims: To study the associations between bone mineral density (BMD) and cardiometabolic risk, and the roles of sun exposure, calcium supplements, and physical activity in those associations.
Scientific rationale: The causes of cardiometabolic disease are complex and still not fully studied.
It is important to identify modifiable risk factors for cardiometabolic disease. Low BMD is linked to cardiometabolic diseases such as type 2 diabetes, myocardial infarction, coronary heart disease, heart failure, and stroke. However, the causal associations are not yet confirmed. Therefore, as a largely preventable condition, low BMD could be a novel target to prevent cardiometabolic disease.
Project duration: 24 months
Public health impact: Our research will clarify the associations between BMD and cardiometabolic disease, and the roles of sun exposure, calcium supplements, and physical activity using this large cohort of UK biobank. The findings may help to build evidence-based strategies to reduce the burden of cardiometabolic disease.
