Association of currently and lifetime psychological issues with cancer-specific morbidity and mortality

Psychological issues (e.g., depression, insomnia, anxiety, etc.) have become increasingly common in modern society and are associated with increased disease burdens worldwide, and several studies have suggested a positive association between psychological disorders (e.g., depression, insomnia) and the risk of several diseases. psychological problems such as depression could impact the immune system, the endocrine system, cancer metastasis, treatment tolerance, and other processes. The coexistence of multiple psychological disorders (i.e., depression, insomnia, anxiety) are very common among general population. However, it is still unclear causation and the extent to which comorbidity of common psychological issues (i.e., depression, anxiety, insomnia, adolescent and adult Traumatic events) could increase the risk of cancers and mortality. Therefore, we would like to conduct a population-based cohort study to investigate the association of psychological issues (i.e., depression, anxiety, insomnia, adolescent and adult traumatic events) with cancer-specific morbidity and mortality. The study will last for 36 months. Our study will provide the robust results on the association between psychological disorder and all-cause mortality and incidence of and mortality from all cancer, and subtypes of cancer. The findings will be helpful for future primary prevention and intervention among community-based population.