This study attempts to identify the potential correlation between body composition, physical exercise, diet and chronic locomotor system diseases (such as osteoarthritis and spinal degeneration) based on the analysis of UBK data, explore the prevention strategies and intervention programs for chronic locomotor system diseases, and provide a theoretical basis for the clinical treatment of these diseases.
Chronic locomotor system diseases are centered on the functional degeneration or chronic injury of the “joint-bone-muscle” complex, characterized by a long disease course and poor curability. Common types include osteoarthritis (OA) (featuring articular cartilage wear and synovial inflammation), osteoporosis (OP) (bone mass loss and increased bone fragility), and spinal degeneration. Currently, clinical treatment for patients in the early and middle stages mainly focuses on symptomatic management; however, pain and limited mobility persist long-term in patients, reducing their quality of life. Therefore, this study starts from the perspectives of body composition, physical exercise and diet, attempting to explore new prevention strategies and intervention programs to delay disease progression and improve patients’ quality of life.
This study will use the large-scale UK Biobank cohort, combining baseline questionnaires, body composition measurements, imaging data, and follow-up health records to systematically evaluate the impact of physical activity, diet, and body composition on musculoskeletal degeneration. Key objectives include:
1.Assessing the independent associations of physical activity and diet with disease risk;
2.Investigating the mediating role of body composition;
3.Exploring variations across age, sex, and genetic susceptibility.
4.Attempting to explore new prevention strategies and intervention programs to delay disease progression
