Research questions: Environmental factors play a crucial role in human health, yet their long-term effects on various health outcomes remain incompletely understood. Additionally, the underlying mechanisms and the interactions of environmental factors with genetic susceptibility and lifestyle factors require further exploration.
Objectives: To explore the associations between environmental exposures and multiple health outcomes, including neuropsychiatric diseases, brain disorders, and bone-related diseases. Additionally, this project will investigate the roles of genetic factors and lifestyle behaviors in these associations.
Scientific Rationale: Environmental factors play a crucial role in human health, yet their long-term effects on various health outcomes remain incompletely understood. Growing evidence suggests that air pollution, greenness, noise, and other environmental exposures contribute to the development of neuropsychiatric diseases (e.g., depression, anxiety), brain structure, and bone-related conditions (e.g., osteoporosis, fractures). However, the underlying mechanisms and the interactions of environmental factors with genetic susceptibility and lifestyle factors require further exploration. Exploring these questions is critical for disease prevention and public health interventions. This project aims to provide a systematic assessment of these relationships using the UK Biobank dataset.
