Early onset colorectal cancer is becoming increasingly common, making it crucial to understand its causes. The gut microbiome is likely involved in the development of key factors that contribute to this type of cancer. Are there specific gut microbiome biomarkers that can be used for the early diagnosis and screening of early-onset CRC? My research plan is to use data from the database to explore the role of gut microbiome on the development and progression of colorectal cancer and identified the specific intestinal flora that had a causal relationship with the risk and prognosis of colorectal at the level of gene prediction, which may provide helpful biomarkers for early disease diagnosis and potential therapeutic targets.
Dysbiosis of the gut microbiome is a hallmark of colorectal cancer development. As precancerous lesions like adenomas progress to colorectal cancer, a decline in microbial diversity and an increase in pathogenic bacteria associated with cancer have been observed. These pathogenic bacteria contribute to tumor initiation and progression through several mechanisms: they produce carcinogenic genotoxins, interact with host cell receptors via bacterial adhesins, metabolize dietary components to generate tumor metabolites, and engage with genetic or epigenetic changes.
