Non-communicable diseases and mortality pose major global disease burdens. Increasing studies have explored associations between non-communicable diseases, mortality, and influencing factors using epidemiological methods like cohort studies and causal inference approaches such as Mendelian randomization. Early interventions for non-communicable diseases can effectively improve prognosis, reduce disease burden, and lower mortality risk. Hence, this project aims to elucidate causal relationships between risks of non-communicable diseases (including hypertension, stroke, coronary heart disease, diabetes, dementia, Alzheimer’s disease, Parkinson’s disease, schizophrenia, depressive disorders, chronic obstructive pulmonary disease, cancer) and mortality with candidate risk factors encompassing lifestyle (e.g., physical activity, sedentary behavior, sleep, smoking, alcohol), sociodemographic characteristics (e.g., gender, age, education, poverty), and nutrition (e.g., nutrients, dietary patterns). Objectives are: 1) explore associations of lifestyle factors with non-communicable disease and mortality risks, 2) investigate sociodemographic impacts on these risks, 3) evaluate nutrition factor relationships with these risks, 4) provide novel index, statistical methods, and predictive models from lifestyle, sociodemographic, and nutritional perspectives to reduce global non-communicable disease and mortality burdens. The research will utilize appropriate statistical methods to uncover the associations or pathways between the aforementioned factors and non-communicable diseases, spanning a duration of 36 months. We aim to significantly reduce the global burden of non-infectious diseases and lower mortality risks. This comprehensive approach underscores our commitment to advancing the understanding of chronic diseases through a multifaceted analysis of lifestyle, sociological, and nutritional impacts, ultimately contributing to the development of effective intervention strategies and public health policies.
