Our research aims to investigate the relationships between brain structure, function, and mental health disorders through studies utilizing UK Biobank’s extensive neuroimaging data.
First, we will examine the neurobiological basis of self-harm and suicidal behaviors. While previous research has explored brain-behavior relationships in suicidality, findings have been inconsistent due to limited sample sizes. To establish a clearer understanding of these associations, we will identify genetic factors influencing brain structure and function and examine their potential causal relationship with self-harm and suicidality. Additionally, we will track longitudinal outcomes following self-harm incidents to understand how different self-harm methods and healthcare interventions influence patient outcomes, advancing our understanding of these behaviors and informing intervention strategies.
Second, we will investigate the neural mechanisms underlying the increased dementia risk observed in individuals with mental disorders. Current evidence suggests that brain structural and functional alterations may mediate this relationship. However, these findings have been largely derived from cross-sectional studies, limiting causal inference. Our longitudinal analysis will examine how mental disorders contribute to dementia risk through specific patterns of brain changes, potentially identifying early markers and intervention targets.
Third, we will explore sex-specific associations between sexual trauma and amygdala structure and function. Previous studies have suggested that traumatic events, such as sexual violence, may lead to structural and functional abnormalities in the amygdala, which may contribute to the development of psychiatric disorders. However, findings are inconsistent due to limited power and consideration of sex differences. Our analysis will leverage UK Biobank’s large sample size to conduct sex-stratified analyses of trauma-related amygdala changes.
