This study investigates risk factors for cardiovascular-kidney-metabolic (CKM) conditions and explores how multimorbidity, including sepsis, chronic obstructive pulmonary disease (COPD), and obesity, impacts life expectancy and mortality. The research seeks to address the following questions: What are the primary risk factors (e.g., adipose tissue distribution, sedentary lifestyle, physical activity levels) for CKM conditions, sepsis, COPD, and obesity? How does the concurrence of CKM diseases with sepsis, COPD, and obesity affect life expectancy and mortality? What roles do modifiable lifestyle factors and body composition play in the progression of these conditions?
Objectives: To identify and quantify modifiable lifestyle risk factors for CKM conditions, sepsis, COPD, and obesity. To examine the impact of concurrent CKM diseases, sepsis, COPD, and obesity on mortality and life expectancy.
To investigate the relationship between body composition (e.g., adiposity) and CKM conditions, sepsis, COPD, and obesity, focusing on physical activity and sedentary behavior.
Scientific Rationale: CKM conditions, sepsis, COPD, and obesity are major contributors to global mortality, significantly reducing life expectancy. With an aging population, multimorbidity involving these conditions poses a critical public health challenge. While traditional risk factors like hypertension and dyslipidemia are well documented, the impact of modifiable lifestyle factors and body composition on these diseases remains underexplored. This study aims to fill these knowledge gaps, providing valuable insights for the prevention and management of CKM multimorbidity and its associated health outcomes.
