Gastrointestinal diseases, including the deadly gastrointestinal cancers and related benign conditions, are huge disease burden globally. The causes of theses diseases are not completely understood, and the current prevention and treatment strategies remain to be improved. With the use unique comprehensive data from a large number of participants in UK Biobank, we aim to explore the genetic and non-genetic causes of gastrointestinal diseases, and also examine gene-environment interaction in the development of these diseases. We will develop and validation risk prediction models for these diseases which may be helpful for tailored prevention, early detection and treatment. We will also investigate the factors influencing the outcomes of these diseases. The research methodologies involve observational studies, Mendelian randomization analysis, as well as phenome- and genome-wide association analyses. The research findings will provide valuable scientific evidence supporting improved prevention and treatment of gastrointestinal diseases.
