Age-related changes in body composition are fundamental determinants of healthy aging trajectories. Concurrently, aging processes and adipose redistribution can both contribute to gut dysbiosis. While these biological changes are inevitable, modifiable factors including lifestyle behaviors and socioeconomic determinants may significantly influence these trajectories and their health consequences. Understanding how modifiable factors interact with body composition changes and gut microbiota is crucial for developing targeted interventions that promote successful aging.
Therefore, this investigation aims to examine the complex interplay between longitudinal body composition dynamics (fat mass, lean mass and mineral density), gut microbiota profiles, and health outcomes including cancer, cardiovascular disease, and mortality within the UK Biobank cohort.
Research Objectives
(1) characterize age-related trajectories of fat mass, lean mass, and bone mineral density across different demographic groups
(2) identify modifiable factors (including lifestyle behaviors and socioeconomic status) and gut microbiota signatures associated with favorable compositional maintenance
(3) evaluate the combined effects of modifiable factors, body compositional changes, and microbial diversity on healthy aging
Results will inform evidence-based intervention strategies targeting body composition optimization and microbiome modulation for healthy aging, with implications for precision medicine approaches for aging populations.
