Clonal hematopoiesis is an age-associated genomic phenomenon increasingly linked to hematologic malignancies and other adverse health outcomes. The longitudinal dynamics of clonal evolution and their biological and contextual determinants remain incompletely understood at the population level.
This project aims to leverage longitudinal genomic and phenotypic data to characterize clonal hematopoiesis trajectories, evaluate their associations with hematologic malignancies, and assess how biological markers, contextual determinants, and analytic strategies influence longitudinal inference.
Objectives
(1) To characterize longitudinal patterns of clonal hematopoiesis across aging and to evaluate their relationship with hematologic malignancy risk in the general population
(2) To examine how biomarkers and broader non-laboratory determinants relate to clonal hematopoiesis trajectories and hematologic malignancy risk.
(3) To explore the robustness of analytic strategies for identifying age-associated clonal genomic features in longitudinal analyses of clonal hematopoiesis.
Through this integrative and longitudinal approach, the study aims to advance understanding of clonal hematopoiesis and its relationships with aging, immune-related processes, and broader determinants of health, with implications for hematologic malignancy development.
