Cardiovascular diseases are among the leading causes of death globally. While numerous studies indicate that unhealthy lifestyles, environmental factors, and genetic variations are closely linked to cardiovascular disease risk, the specific mechanisms remain unclear. This research aims to combine genetic and omics data with epidemiological data to enhance understanding of the etiology of major cardiovascular diseases.
Research Questions – How do genetic factors influence the pathogenesis of cardiovascular diseases? – What role do omics data (genomics, transcriptomics, proteomics, and metabolomics) play in assessing cardiovascular disease risk? – How do epidemiological data integrate with genetic and omics data to reveal potential causes of cardiovascular diseases? – How do environmental factors interact with genetic and omics characteristics to affect cardiovascular disease occurrence?
Research Objectives – Systematically analyze genetic and omics data to identify key genes and biomarkers related to cardiovascular diseases. – Explore the combined effects of genetic susceptibility and environmental factors on cardiovascular disease risk using epidemiological data. – Assess the roles of various omics characteristics in the pathogenesis of cardiovascular diseases and uncover their biological mechanisms. – Provide insights for the prevention and treatment of cardiovascular diseases and identify potential intervention targets.
Scientific Basis – Genetic Research: Studies show that genetic variations significantly influence cardiovascular disease pathogenesis. Genome-wide association studies (GWAS) can identify relevant genetic markers.
Omics Technologies: These technologies offer a comprehensive view of complex biological processes, aiding in the understanding of cardiovascular disease mechanisms.