Research Questions:
1. What novel risk factors contribute to various types of cancer?
2. Can we identify new biomarkers for early detection and treatment response?
3. How do genetic, metabolomic, proteomic, and epidemiological factors interplay in cancer development?
Objectives:
– Unearth risk determinants for solid tumors and hematologic cancers.
– Identify prospective biomarkers for early cancer detection and prognosis.
– Elucidate etiological links among genetic, metabolomic, proteomic, and epidemiological data in cancer pathogenesis.
Scientific Rationale:
Cancer is a leading global health threat, with GLOBOCAN 2022 estimating 1 in 5 people will develop cancer. Our understanding of cancer is limited, necessitating a comprehensive approach. This project will leverage UK BioBank’s rich dataset, integrating genetic, metabolomic, proteomic, MRI, and epidemiological data. By applying a multifaceted analytical approach, we aim to deepen our understanding of cancer complexity, tailor interventions, refine diagnostics, and bolster management protocols, ultimately improving cancer-related health outcomes.