This project aims to leverage the extensive data available from the UK Biobank to investigate the common mechanisms underlying cardiovascular diseases, cancers, musculoskeletal disorders, and neurodegenerative diseases. These diseases represent some of the leading causes of morbidity and mortality worldwide, yet the complex genetic, environmental, and clinical factors contributing to their pathogenesis remain poorly understood.
Our primary research question is: How do genetic, lifestyle, and imaging factors interact to influence the risk and progression of cardiovascular diseases, cancers, musculoskeletal disorders, and neurodegenerative diseases? Specifically, we will:
1. Identify genetic variants associated with these diseases through genome-wide association studies (GWAS).
2. Investigate the relationships between clinical data (e.g., medical history, lifestyle factors) and disease onset or progression.
3. Analyze the role of imaging data in the detection of structural changes related to these diseases, with an emphasis on neurodegenerative and cardiovascular conditions.
The scientific rationale behind this study is to bridge the gap in understanding the intersection of genetics, clinical factors, and imaging biomarkers in disease pathogenesis. By integrating these data, we aim to improve early detection strategies, identify novel biomarkers for disease prediction, and provide insights into personalized treatment approaches. This research is essential for advancing precision medicine, particularly in diseases that currently have high morbidity and mortality rates, such as cardiovascular diseases, cancers, and neurodegenerative conditions.
