This project aims to conduct a comprehensive analysis of key determinants influencing the onset and progression of both non-communicable diseases (NCDs) and communicable diseases (CDs). It will explore genetic, environmental, clinical, laboratory, imaging, and lifestyle factors and investigate their interactions in shaping disease outcomes.
Research Questions:
1. What are the key genetic, environmental, clinical, and lifestyle factors contributing to the onset and progression of NCDs (e.g., cardiovascular diseases, diabetes) and CDs (e.g., infectious diseases, sepsis)?
2. How do these determinants interact, and what are their combined effects on disease risk and progression?
3. Can identifying these factors provide novel insights for personalized prevention and therapeutic strategies?
Objectives:
1. Identify and analyze genetic, environmental, clinical, laboratory, imaging, and lifestyle determinants for NCDs and CDs.
2. Investigate the interactions between these factors and their combined impact on disease risk and progression.
3. Provide insights for personalized prevention, early diagnosis, and therapeutic interventions.
Scientific Rationale: The increasing global burden of NCDs and CDs necessitates a deeper understanding of their multifactorial nature. By examining the interplay between genetic predispositions, environmental exposures, lifestyle factors, and clinical data, this research aims to uncover the mechanisms underlying disease development. This will contribute to precision medicine by offering tailored interventions and improving public health outcomes. Furthermore, the findings may help identify new drug targets and diagnostic tools for these diseases, advancing our understanding of their pathogenesis.