The prevalence of common diseases like cardio-cerebrovascular diseases, respiratory diseases, metabolic diseases, and certain cancers continues to rise globally, posing significant challenges to public health. Research indicates that these diseases are influenced not only by genetic factors but also by environmental and lifestyle factors across an individual’s life course. Understanding the intricate interplay between life course risk factors and multi-omics (genomics and metabolomics, etc.) could provide crucial insights into disease etiology, progression, and potential interventions. This study aims to identify key life course risk factors contributing to the onset and progression of common diseases, investigate how multi-omics data (e.g., genomics and metabolomics, etc.) interact with and are influenced by these risk factors, and analyze the potential synergistic or antagonistic effects of these interactions on disease susceptibility and severity. The project duration is 36 months. This research may lead to improved disease management and public health interventions, potentially reducing the burden of common diseases on a global scale.
