The molecular mechanism of complex diseases, like Alzheimer’s disease, remains unclear regarding numerous genetic and environmental risk factors, since each contributes to the disease with a tiny effect. The detection of interactions between risk genes, and between genotypes (e.g. APOE4) and risk factors (e.g. HSV-1 infection history), requires longitudinal cohort with deep phenotyping and genotyping. Using the UK Biobank cohort with genome, exposome, and deep phenotype information, this project aims to identify the risk factors underlying typical neuropsychiatric disorders, and explore the interaction between the genetic and environmental factors. The project will last for about 36 months, with comprehensive data analyses and experimental validations of the findings. The research will provide detailed understanding of the mechanism of complex neuropsychiatric diseases, making a complement to the traditional study which mainly focused on single risk factor. Such knowledge may provide potential targets for the precise medicine of these complex disease.
