1. Explore the role of established risk factors and pathways for multimorbidity (e.g., cardiovascular disease, diabetes, hypertension, chronic respiratory diseases, cancer, osteoarthritis, chronic kidney disease, mental health disorders, neurological disorders, and dementia) in the UK population.
2. Discover the non-modifiable risks, lifestyle-related risk factors, medical history-related risk factors, imaging-related risks, genetic predispositions and metabolomic profiles, and explore the causal risks and pathways in multimorbidity (e.g., cardiovascular disease, diabetes, hypertension, chronic respiratory diseases, cancer, osteoarthritis, chronic kidney disease, mental health disorders, neurological disorders, and dementia) in the UK population.
3. Establish a comprehensive network analysis in the UK Biobank cohort by integrating current risk factors, genomic biomarkers and metabolomic profiles-related risks for multimorbidity (e.g., cardiovascular disease, diabetes, hypertension, chronic respiratory diseases, cancer, osteoarthritis, chronic kidney disease, mental health disorders, neurological disorders, and dementia).
