Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes ~24 hr rhythms in many behavioral and physiological processes. Disruption of the circadian rhythm can cause health conditions in several parts of the body in the long term, such as the cardiovascular and gastrointestinal systems, and is more susceptible to diabetes, obesity, and mental health conditions. Genetic variation is one of the most important factors that influence each person’s circadian rhythm. However, genetic variations associated with circadian rhythm disruption are largely unknown.
Aims In this study, we will determine the role of genetic variations, rhythmic proteins, and metabolites in related diseases.
Research objectives: donors who have genotype, protein, or metabolites abundance data
Study design: We will retrieve the genotype, metabolomic, and proteomic data of thousands of humans and use computing methods in bioinformatics to identify genetic variations that are associated with the destruction of circadian rhythmicity and the role of these variations in related diseases.