Does higher dietary intake of saturated fatty acids (SFAs) reduce the risk of developing B-cell lymphomas, including diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and Burkitt lymphoma, in the general population?
1. To assess the association between intake of individual SFAs (e.g., palmitic acid, myristic acid) and B-cell lymphoma incidence.
2. To evaluate subtype-specific associations with DLBCL, FL, and Burkitt lymphoma.
3. To adjust for major confounders such as age, sex, total energy intake, BMI, smoking, and alcohol.
4. To evaluate potential dose-response trends across SFA intake quantiles.
Ferroptosis is a form of regulated cell death dependent on lipid metabolism. While previously linked to unsaturated fatty acids, recent findings from our group suggest that saturated fatty acids, particularly PA and MA, can also trigger ferroptosis in specific biological contexts. Preliminary experimental data indicate B-cell lymphomas are specifically sensitive to SFA-induced ferroptosis. However, no population-level studies have examined the relationship between dietary SFA intake and B-cell lymphoma risk. This study aims to fill the gap by leveraging the scale and detail of the UK Biobank.