This project aims to systematically explore the genetic, environmental, and behavioral factors influencing Non-Communicable Diseases (NCDs) such as kidney disorders, cardiovascular diseases, diabetes, cancers, and neurodegenerative conditions. Specifically, it will: 1. Identify genetic variants and multi-omics markers associated with NCD risk factors using genome-wide association studies (GWAS) and multi-omics analyses.2. Evaluate the cost-effectiveness of interventions targeting genetic predispositions combined with environmental factors (e.g., diet, pollution, smoking) on NCD progression.3.Investigate molecular pathways and mechanisms underlying NCD pathogenesis using multi-omics technologies4. Analyze radiomics data to identify imaging features linked to NCDs.5.Develop predictive models for early NCD risk identification and implement interventions targeting modifiable environmental risk factors.Background: NCDs are a leading cause of global mortality and a significant public health concern. Despite medical advances, their complex, multifactorial etiology involving genetic, environmental, and lifestyle factors remains insufficiently understood. Advances in multi-omics and radiomics technologies allow for a more integrated approach, combining genetic, epigenetic, proteomic, metabolomic, and imaging data to explore gene-environment interactions. This project will analyze data from the UK Biobank, including genetic, phenotypic, imaging, and environmental data from 500,000 participants.
