A.Objectives!The aim of this study is to explore the association between environmental exposures !noise pollution! particulate matter!and Helicobacter pylori infection!and metabolic-associated fatty liver disease (MAFLD), and other chronic liver diseases within the UK Biobank cohort. Additionally, this study aims to identify mediating factors and modifiable metabolic mediators that could serve as intervention targets, thereby deepening the understanding of environmental stressors in the epidemiology of MAFLD and providing novel directions for the prevention and treatment of MAFLD and other chronic liver diseases.
B.Scientific Rationale: Existing evidence gaps exist in understanding how urban environmental exposures influence MAFLD development. By investigating noise and air pollution alongside Hp infection, we aim to fill critical knowledge gaps in MAFLD’s environmental epidemiology.
If proven, these findings could revolutionize urban planning policies. For example, implementing noise reduction measures or stricter air quality standards might mitigate MAFLD risk. Since MAFLD affects over 25% of the global population, evidence-based interventions could significantly reduce healthcare burdens, aligning with clinical translation goals to improve public health outcomes.
