In the field of evolutionary biology, a hypothesis emerges suggesting that advancements in biomedicine, such as assisted reproductive technologies (ART) like IVF, may alter the dynamics of natural selection by allowing the persistence of mildly deleterious mutations within populations. Traditionally, reproductive development is under intense natural selection pressure, with most harmful mutations being eliminated during early embryonic development and individual growth. This selective process is essential for maintaining the overall health and viability of species. However, as biomedicine enhances reproductive rates and improves offspring survival, it may reduce the selective pressures that typically purge these mutations. This hypothesis posits that the retention of mildly harmful mutations could lead to increased genetic diversity within populations, potentially providing adaptive advantages in changing environments. Importantly, these mutations may also influence health outcomes-a largely unexplored area that warrants further investigation.
The primary aim of our research is to investigate whether novel mutations have emerged in recent decades as a result of advancements in biomedical systems, and to assess the potential impacts of these mutations on health. We will conduct a comparative analysis of the genetic variation spectrum across populations of different ages. By examining the deleterious effects of mutations that appear in various age groups, we aim to determine the potential health impacts and how these mutations were preserved in population.
This study has the potential to reveal significant patterns of genetic diversity and their correlation with health outcomes, thereby illuminating the long-term evolutionary implications of biomedical interventions. Furthermore, the insights gained from our research could inform public health strategies and enhance our understanding of how genetic factors interact with contemporary medical practices.
